Pyramid and Zopache make heavy use of interfaces, but Zopache also makes use of Zope.schema.  Pyramid uses zope.interface for view dispatch and security.  Zopache also uses zope.interface for view dispatch, but not for security. 


Zopache uses Zope.schema and z3c.form for defining user interfaces.  Pyramid does not.  Grok and Zopache use interfaces and schemas for generating forms.  Pyramid supports any python forms package.  Zopache uses interfaces and schemas for defining ZClasses.  

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